DNA-repair enzyme turns to translation

Borrowing a DNA Repair Enzyme to Fine-Tune Antibody Specificity

The history of life is fi lled with examples of one species diverging into several, even thousands, each with unique traits geared to the demands of its ecological niche. In the textbook case of adaptive radiation, an ancestral fi nch species landed on the Galapagos Islands just a few million years ago, and evolved into 13 new species with specialized beaks adapted to exploiting the various see...

Enzyme Structures: DNA repair flips out

New insights into the workings of the repair enzymes that police the genome for damage to DNA come from the recently determined structures of two uracil-DNA glycosylases.

Epigenetic Silencing of the DNA Repair Enzyme

Regulation of the expression of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) has been investigated in a number of human lymphoblastoid cell lines. In a number of Mex cell lines that do not express methyltransferase activity, CpG sequences in the mgmt gene were hypomethylated with respect to methyltransferaseexpressing Mex+ lines. In the cell line GM1953(S), in which the m...

Tuberin regulates the DNA repair enzyme OGG1.

The tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. The TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas. We investigated a potential role for tuberin in regulating a key DNA repair pathway. Downregulation of tuberin in human renal epithelial cells using...

The twists and turns of enzyme function.